Targeting Costimulatory Molecules to Improve Antitumor Immunity

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Targeting Costimulatory Molecules to Improve Antitumor Immunity

The full activation of T cells necessitates the concomitant activation of two signals, the engagement of T-cell receptor by peptide/major histocompatibility complex II and an additional signal delivered by costimulatory molecules. The best characterized costimulatory molecules belong to B7/CD28 and TNF/TNFR families and play crucial roles in the modulation of immune response and improvement of ...

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Induction of antitumor immunity by recombinant vaccinia viruses expressing B7-1 or B7-2 costimulatory molecules.

Activation of T cells requires at least two signals: an antigen-specific signal delivered through the T-cell receptor and a costimulatory signal mediated through molecules designated B7-1 and B7-2. Previous studies have shown that introduction of B7-1 and B7-2 into tumors using retroviral vectors has led to enhanced antitumor effects. A limiting factor for potential clinical applications using ...

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Antitumor immunity after vaccination with B lymphoma cells overexpressing a triad of costimulatory molecules.

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ژورنال

عنوان ژورنال: Journal of Biomedicine and Biotechnology

سال: 2012

ISSN: 1110-7243,1110-7251

DOI: 10.1155/2012/926321